Two women from Anderson were involved in an accident on Route NN, about a quarter-mile east of Anderson Saturday evening.
The Missouri State Highway Patrol report says a westbound 2003 Ford Escape driven by 36-year-old Ashley Hoyer went off the road and hit two trees.
Hoyer was not hurt.
An occupant, 63-year-old Teresa N. Chadwell, was seriously injured.
She was transported by EMS to Freeman West in Joplin.