A portion of I-44 was closed down overnight for a Joplin Police Major Crash Team investigation.
Emergency responders were dispatched to a serious accident around 2:30 a.m. and the eastbound lanes were shut down.
It is reported that the Newton County coroner was dispatched to the crash scene which reportedly took the life of a motorcycle driver.
The accident took place near the 4.5 mile marker.
The highway officially opened again just before 6 a.m.
The name of the man killed has not yet been released.
NewsTalk KZRG will have further details as they become available.